Author:
Adair, Thomas H.
Imprint:San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, c2011.
Description1 electronic text (x, 71 p. : ill.) : digital file.
Note:Part of: Colloquium digital library of life sciences.
Note:Series from website.
Note:1. Overview of angiogenesis -- History -- Origin of blood vessels -- The angiogenic process -- Types of angiogenesis -- Sprouting angiogenesis -- Intussusceptive angiogenesis --
Note:2. Angiogenesis assays -- In vitro assays -- Endothelial cells are heterogeneous -- In vitro conditions rarely reflect in vivo environment -- Endothelial cell proliferation assays -- Endothelial cell migration assays -- Endothelial tube formation assays -- Rat and mouse aortic ring assay -- In vivo assays -- Corneal angiogenesis assay -- Chick chorioallantoic membrane (CAM) angiogenesis assay -- Matrigel plug assay --
Note:3. Regulation: metabolic factors -- Capillary growth is proportional to metabolic activity -- Increasing metabolic activity stimulates blood vessel growth -- Decreasing metabolic activity causes vascular regression -- Long-term increases in blood pressure lead to vascular rarefaction -- Oxygen is a master signal in growth regulation of the vascular system -- Increases in muscular activity cause decreases in muscle oxygenation -- Oxygen regulates angiogenic growth factor production -- VEGF-A released from hypoxic tissues is a key regulator of angiogenesis -- Negative feedback regulation of VEGF-A -- Oxygen plays a central role in feedback regulation of vascular growth and regression -- Role of adenosine in metabolic regulation of vascular growth --
Note:4. Regulation: mechanical factors -- Control of blood vessel growth -- Epithelial sodium channel protein biology -- Epithelial sodium channels can form a mechanosensory complex -- Epithelial sodium channels can mediate mechanotransduction in mammals -- Do epithelial sodium channels mediate angiogenesis -- Physical forces acting on the walls of blood vessels -- Shear stress is sensed by the endothelium -- Increased blood flow (shear stress) can stimulate angiogenesis -- Possible role of endothelial cell shape in regulating blood vessel growth and regression -- Mechanical factors have an accessory role in angiogenesis -- Control of lymphangiogenesis -- Flow-guided lymphangiogenesis -- High salt load stimulates lymphangiogenesis in skin --
Note:Glossary -- References -- Author biographies.
Bibliography Note:Includes bibliographical references (p. 47-70a).
Note:Angiogenesis is the growth of blood vessels from the existing vasculature. The field of angiogenesis has grown enormously in the past 30 years, with only 40 papers published in 1980 and nearly 6000 in 2010. Why has there been this explosive growth in angiogenesis research? Angiogenic therapies provide a potential to conquer cancer, heart diseases, and more than 70 of life's most threatening medical conditions. The lives of at least 1 billion people worldwide could be improved with angiogenic therapy, according to the Angiogenesis Foundation. In this little book, we provide a simple approach to understand the essential elements of the angiogenic process, we critique the most powerful angiogenesis assays that are used to discover proangiogenic and antiangiogenic substances, and we provide an in-depth physiological perspective on how angiogenesis is regulated in normal, healthy tissues of the human body. All tissues of the body require a continuous supply of oxygen to burn metabolic substrates that are needed for energy. Oxygen is conducted to these tissues by blood capillaries: more capillaries can improve tissue oxygenation and thus enhance energy production; fewer capillaries can lead to hypoxia and even anoxia in the tissues. This means that angiogenic therapies designed to control the growth and regression of blood capillaries can be used to improve the survival of poorly perfused tissues that are essential to the body (heart, brain, skeletal muscle, etc.) and to rid the body of unwanted tissues (tumors).
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