Contributor
Fischer, János, editor.
ImprintWeinheim, Germany : Wiley-VCH, [2015]
Descriptionxix, 235 pages : illustrations (some color) ; 25 cm
Note:Part I: General Aspects -- Serendipitous Target-Based Drug Discoveries / János Fischer, David P. Rotella -- Drug Discoveries and Molecular Mechanism of Action / David C. Swinney -- Part II: Drug Class -- Insulin Analogs: Improving the Therapy of Diabetes / John M. Beals -- Part III: Case Histories -- The Discovery of Stendra (Avanafil) for the Treatment of Erectile Dysfunction / Koichiro Yamada, Toshiaki Sakamoto, Kenji Omori, Kohei Kikkawa -- Dapagliflozin, A Selective SGLT2 Inhibitor for Treatment of Diabetes / William N. Washburn -- Elvitegravir, A New HIV-1 Integrase Inhibitor for Antiretroviral Therapy / Hisashi Shinkai -- Discovery of Linagliptin for the Treatment of Type 2 Diabetes Mellitus / Matthias Eckhardt, Thomas Klein, Herbert Nar, Sandra Thiemann -- The Discovery of Alimta (Pemetrexed) / Edward C. Taylor -- Perampanel: A Novel, Noncompetitive AMPA Receptor Antagonist for the Treatment of Epilepsy / Shigeki Hibi -- Discovery and Development of Telaprevir (Incivek): A Protease Inhibitor to Treat Hepatitis C Infection / Bhisetti G. Rao, Mark A. Murcko, Mark J. Tebbe, Ann D. Kwong -- Antibody-Drug Conjugates: Design and Development of Trastuzumab Emtansine (T-DM1) / Sandhya Girish, Gail D. Lewis Phillips, Fredric S. Jacobson, Jagath R. Junutula, and Ellie Guardino.
Bibliography Note:Includes bibliographical references and index.
