Contributor
Lee, Juhyun, 1979- editor.
ImprintSingapore : Jenny Stanford Publishing, [2021]
Imprint2021
Descriptionx, 249 pages : illustrations ; 24 cm
Note:Shear stress, mechanosensors, and atherosclerosis / Suowen Xu and Zheng Gen Jin -- Role of Krppel-like factors in endothelial cell function and shear stress-mediated vasoprotection / Eugene Chang and Mukesh Jain -- Aortic valve endothelium mechanobiology / Rachel L.E. Adams and Craig A. Simmons -- Mechanotranduction of cardiovascular development and regeneration / Quinton Smith, Justin Lowenthal, and Sharon Gerecht -- Mechanotransduction in heart formation / Sandra Rugonyi -- Mechanotransduction in cardiovascular development and regeneration: a genetic zebrafish model / Rongsong Li, Kyung In Baek, Chih-Chiang Chang, Bill Zhou, and Tzung Hsiai -- Mechanosensitive microRNAs in health and disease / Myung-Jin Oh, Tzu-Pin Shentu, Dakish Chauhan, and Yun Fang -- Biomechanics in cardiac development using 4D light-sheet imaging / Victoria Messerschmidt and Juhyun Lee.
Bibliography Note:Includes bibliographical references and index.
Note:Modern mechanobiology converges both engineering and medicine to address personalized medicine. This book is built on the previously well-received edition, Hemodynamics and Mechanobiology of Endothelium. The central theme is "omic" approaches to mechanosignal transduction underlying tissue development, injury, and repair. A cadre of investigators has contributed to the chapters, enriching the interface between mechanobiology and precision medicine for personalized diagnosis and intervention. The book begins with the fundamental basis of vascular disease in response to hemodynamic shear stress and then details cardiovascular development and regeneration, valvular and cardiac morphogenesis, mechanosensitive microRNA and histone unfolding, computational fluid dynamics, and light-sheet imaging. This edition represents a paradigm shift from traditional biomechanics and signal transduction to transgenic models, including novel zebrafish and chick embryos, and targets a wider readership from academia to industry and government agencies in the field of mechanobiology.
